Endocrine Abstracts

The aims of the study were to analyze the relationship among insulin resistance, obesity, dysglycemia, dyslipidemia and to evaluate the role of common variants in candidate genes for their ability to predict the metabolic syndrome and cardio-metabolic risk factors.Subjects and methods: 752 non-diabetic individuals (190 males and 562 females; age 35.05+4.47 years, BMI 26.72+5.92 kg/m2) participating in the study were genotyped for variants in p...

Introduction: The improvement of vitamin D status is necessary to overcome an impaired calcium-phosphorus metabolism and disturbances in other tissues functioning; safety of medical intervention should include analysis of metabolic changes.Material and methods: Twenty four apparently healthy volunteers 24.9±2 year were included in the study: Group 1 (11/24) with blood serum levels of 25(OH)D <10 ng/ml and Group 2 (13/24) with 25(OH)D levels 10&#...

Background and aims: To evaluate the level of tubular and glomerular biomarkers of kidney injury as potential nephroprorotective effects of GLP-1R agonist (liraglutide) addition in type 1 diabetic patients compared to standard insulin therapy.Materials and methods: 12 T1DM patients with normo-(AER <20 mg/l, n=7) and microalbuminuria (AER<199 mg/l, n=5) with liraglutide 1.2 mg as add on to insulin for 6 month and 12 patients with...

Decorin is myokine expressed and released in response to muscle contractions. It induces growth and hypertrophy of skeletal muscles in different ways including myostatin inhibition. It is still not clear whether decorin takes part in development of muscle atrophy in endocrine pathologies.Objective: To evaluate decorin levels in patients with endogenous hypercortisolism and GH oversecretion.Materials and methods: Three groups were i...

Background and aims: Microalbuminuria (MA) is not specific predictor of early stages of chronic kidney disease (CKD) in diabetes. We investigate several markers that might be useful in assessing early kidney damage in T1DM and T2DM patients additional to MA.Materials and methods: We examined 111 patients (T1DM/T2DM: 51/60) with AER<20 mg/l (n=80); <199 mg/l (n=18); ≥200 mg/l (n=13). Biomarkers of kidney damage (c...

Abstract: Transsphenoidal surgery is the treatment of choice for Cushing’s disease. Despite the 70–90% remission rates relapses after successful transnasal adenectomy are frequently observed.Aim: To evaluate the dynamics of intra- and early postoperative levels of adrenocorticotrophic hormone (ACTH) and cortizol and their role as predictors or Cushing’s disease remission.Materials/methods: Fifty patients with Cushing...

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 1–4 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 1–4 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. During hypoglycemia, a wide spectrum of physiologic responses are activated that could have potential vascular biological effects. To date, the role played by catecholamines, the sympathetic nervous system, and neuroendocrine hormones on activating adhesion m...